منابع مشابه
The tubulin code.
Microtubules create diverse arrays with specific cellular functions such as the mitotic spindle, cilia and bundles inside neurons. How microtubules are regulated to enable specific functions is not well understood. Recent work has shown that posttranslational modifications of the tubulin building blocks mark subpopulations of microtubules and selectively affect downstream microtubule-based func...
متن کاملDeciphering the Tubulin Code
Enzymes of the tubulin tyrosine ligase-like (TTLL) family posttranslationally modify and thereby mark microtubules by glutamylation, generating specific recognition sites for microtubule-interacting proteins. Garnham et al. report the first structure of a TTLL protein alone and in complex with microtubules, elucidating their mechanism of action.
متن کاملCracking the (tubulin) code of mitosis
Mitosis in high eukaryotes is typically initiated by nuclear envelope breakdown (NEB), consequently allowing the dynamic interaction between microtubules and condensed chromosomes. These spatially scattered chromosomes congress to the spindle equator to establish a metaphase plate before being equally distributed to two daughter cells during anaphase. Congression can be achieved by at least two...
متن کاملThe Altered Hepatic Tubulin Code in Alcoholic Liver Disease
The molecular mechanisms that lead to the progression of alcoholic liver disease have been actively examined for decades. Because the hepatic microtubule cytoskeleton supports innumerable cellular processes, it has been the focus of many such mechanistic studies. It has long been appreciated that α-tubulin is a major target for modification by highly reactive ethanol metabolites and reactive ox...
متن کاملThe tubulin code: Molecular components, readout mechanisms, and functions
Microtubules are cytoskeletal filaments that are dynamically assembled from α/β-tubulin heterodimers. The primary sequence and structure of the tubulin proteins and, consequently, the properties and architecture of microtubules are highly conserved in eukaryotes. Despite this conservation, tubulin is subject to heterogeneity that is generated in two ways: by the expression of different tubulin ...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2007
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.6.17.4633